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By Alan N. Schechter

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Godfrey's thorough study (Godfrey and Harrington, 1970) as well as the later laser-light scattering experiments of Herbert and Carlson (1971) provided strong support for the presence of a monomer-dimer equilibrium in high-salt solvents and showed why earlier workers had gone astray. The severe nonideal behavior, characteristic of asymmetric fibrous proteins, had effectively masked the presence of an associating system. I was captivated by the thought that the myosin dimer might be a fundamental building block of the muscle thick filament and was determined to look into this question over the next few years.

Science 207, 3 7 9 - 3 8 4 . 23. Ball, J. , and Omenn, G. S. (1979). The role of health technology evaluation: a policy perspective. In "Health Care Technology Evaluation" (J. ), pp. 5 - 3 2 . SpringerVerlag, Berlin and New York. 24. Calkins, D. , Dixon, R. , Gerber, C. , Zarin, D . , and Omenn, G. S. (1980). Identification, characterization, and control of potential human carcinogens: A framework for federal decision making. JNCI, J. Natl. Cancer Inst. 64, 169-175. CHAPTER 3 From Polypeptide Chemistry to Muscle Contraction W I L L I A M F.

Persons who are patients in ordinary medical care settings are offered 2. Basic Research as an Investment in the Nation's Future 17 much less formal protection and often much less information than subjects participating in clinical research protocols. The whole transition from the HEW Ethics Advisory Board to the President's Commission, the negotiations with Senator Kennedy's staff and many others over the nominees for appointment to the Commission, and the explanation of the mandate of the Commission involved our office directly.

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