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Download Developing Costimulatory Molecules for Immunotherapy of by Manzoor Ahmad Mir PDF

By Manzoor Ahmad Mir

Developing Costimulatory Molecules for Immunotherapy of ailments highlights the radical inspiration of opposite costimulation and the way it may be successfully exploited to enhance immunotherapy utilizing both humanized antibodies opposed to CD80, CD86, and different costimulatory molecules or CD28 fusinogenic proteins within the remedy of ailments, together with asthma, bronchial asthma, rheumatoid arthritis, a number of sclerosis, lupus nephritis, critical psoriasis, vulgaris tuberculosis, thopoid, transplantation healing, melanoma, and irritation.

The textual content goals to supply the most recent details at the complicated roles and interactions in the CD28 and B7 costimulatory households, with the desire that focusing on those households will yield new remedies for the therapy of irritation, autoimmunity, transplantation, melanoma, and different infectious diseases.

  • Highlights the radical idea of opposite costimulation and the way it may be successfully exploited to boost immunotherapy
  • Provides the most recent info at the complicated roles and interactions in the CD28 and B7 costimulatory families
  • Targets new cures for the remedy of irritation, autoimmunity, transplantation, melanoma, and different infectious diseases

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Extra info for Developing Costimulatory Molecules for Immunotherapy of Diseases

Example text

New battlefields for costimulation. J Exp Med 2006;203: 817À20. Introduction to Costimulation and Costimulatory Molecules Chapter | 1 37 76. Martin-Orozco N, Wang YH, Yagita H, Dong C. Cutting edge: programmed death (PD) ligand-1/PD-1 interaction is required for CD81 T cell tolerance to tissue antigens. J Immunol 2006;177:8291À5. 77. Ansari MJ, Salama AD, Chitnis T, Smith RN, Yagita H. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 2003;198:63À9.

Immunol Rev 2009;229:145À51. 92. Valentonyte R, et al. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet 2005;37:357À64. 93. Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, et al. Cutting edge: induction of B7-H4 on APCs through IL-10—novel suppressive mode for regulatory T cells. J Immunol 2006;77:40À4. 94. Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, et al. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.

B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties. Immunol Lett 2006;104:70À5. 70. Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K, et al. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001;97: 1809À16. 71. Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999;5:1365À9. 72. Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, et al.

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