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Download Chemokine Biology: Basic Research and Clinical Application: by Kuldeep Neote (Editor), Gordon L. Letts (Editor), Bernhard PDF

By Kuldeep Neote (Editor), Gordon L. Letts (Editor), Bernhard Moser (Editor)

Chemokines play a tremendous function in recruiting inflammatory cells into tissues according to an infection and irritation. in addition they play an immense function in coordinating the stream of T-cells, B-cells and dentritic cells, essential to generate an immune reaction (response to damage, allergens, antigens, invading microorganisms). They selectively allure leukocytes to inflammatory foci, inducing either phone migration and activation. they're keen on a number of illnesses, like atherosclerosis, lung and dermis irritation, a number of sclerosis, or HIV. quantity 2 of this two-volume set discusses the pathophysiology of chemokines. it really is divided into elements: a) chemokines in animal illness types, and b) chemokines as drug goals. including quantity 1, which discusses the immunobiology of chemokines, either volumes supply a finished review of chemokine biology.

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Extra resources for Chemokine Biology: Basic Research and Clinical Application: Vol. 2: Pathophysiology of Chemokines (Progress in Inflammation Research)

Example text

The activation of mast cells, eosinophils and basophils and the subsequent release of their granules lead to many of the phenotypic features observed in the allergic response, such as vasodilatation and tissue edema. Participation of eosinophils, basophils and mast cells in the allergic response is not limited to the release of their pre-formed biological mediators. Eosinophils, basophils and mast cells contribute to the allergic response in at least three additional ways: they provide a link between the innate and adaptive immune response during the initial phase of allergic inflammation, they skew the adaptive immune response to new antigens towards a Th2 phenotype and they amplify the allergic response during viral infections through the function of their chemokines.

One current view of chemokines is to regulate the migration and/or accumulation of leukocytes at a particular tissue site for the general function of infection clearance and tissue repair. However, aberrant accumulation of leukocytes, including antigen-specific T cells and monocytes, can induce pathology and result in tissue-specific autoimmune and/or inflammatory disease. Our greatest understanding of the role of chemokines in CNS disorders comes from the EAE model where the temporal and spatial chemokine expression patterns appear to regulate mononuclear cell accumulation and subsequent disease development [16].

Inflamm Res 50(3): 168–174 Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA (1997) High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. J Clin Invest 100(5): 1137–1143 Ochensberger B, Tassera L, Bifrare D, Rihs S, Dahinden CA (1999) Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists.

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