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By C.W. Jameson and Douglas B. Walters (Eds.)

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C Garner. "Carcinogenic Aromatic Amines and Related Compounds," in Chemical Carcinogens, A CS Monograph 173, C E . Searle, Ed. (Washington, D . C : American Chemical Society, 1976), pp. 366-461. 28 3. 4. 5. 6. 7. 8. 9. 10. 11. L. "Prediction of Carcinogenicity Based on Structure, Chemical Reactivity and Possible Metabolic Pathways," J. Environ. Pathol. Toxicol. 3:11-33(1980). , L. Tomatis, J. Huff, and J. Wilbourn. I ARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Chemicals and Industrial Processes Associated with Cancer in Humans, Supplement 1 ( L y o n , France: International Agency for Research on Cancer, 1979), pp.

G S R I recently had a bad experience when a dosage preparation technician mislabeled vehicle control material intended for a skin-paint study, and the vehicle control animals for a gavage study mistakenly received acetone. Fortunately, the animal care technician stopped dosing when the animals were observed to be reacting to the control material compound, but not before 50 vehicle control animals from that study died. A review indicated that two bottles (male and female) for that particular day were the only ones mislabeled and that those were the only vehicle control solutions prepared that day.

0 ml) of this solution was placed on a column containing 40 ml Fisher Adsorption A-50, 80-200 mesh, deactivated with 5% water. The column was eluted with benzene and the first 115 ml of eluent collected. This eluent was concentrated on a steam bath to approximately 4 ml in a Kuderna-Danish concentrator fitted with a three-ball Snyder column. 50 ml. 0 g ) . The column 34 GENERAL CHEMISTRY CONSIDERATIONS PENTACHLOROPHENOL OH CI Impurities anticipated from production process: Chlorinated diphenyl ethers Chlorinated higher phenols Chlorinated dibenzodioxins and dibenzofurans (and hydroxy derivatives) Cln (OH) Figure 3-1.

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