By Takashi Sugimura (auth.), Hideya Endo, Tetsuo Ono, Takashi Sugimura (eds.)
During the decade a substantial physique of data has come into lifestyles relating a category of carcinogenic molecules mainly represented via 4-nitroquinoline i-oxide. unique papers in this topic are various and greatly scattered over many branches of technological know-how; it was once felt that those papers could be reviewed and the data introduced jointly in a single quantity sooner than it grew to become too unwieldy. This we now have tried to do during this monograph. Our target has been to incorporate all correct papers released to this point, in order that it will probably function an epitome of the current prestige of data in this vital topic. we've got been lucky in securing the cooperation of a number of colleagues who've contributed chapters, every one facing one element of the topic. we have now been doubly lucky in that those members, like ourselves, have been at one time or one other contributors of the crowd belonging to the medical employees of Dr. WARO NAKA HARA, Director of the nationwide melanoma heart study Institute, Tokyo, Japan.
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Extra resources for Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide
Furthermore, single-stranded DNA was shown to be more sensitive to photoirradiation than the double-helix DNA. This suggested that the intercalation of 4-nitroquinoline I-oxide between the bases of double-helix DNA is not necessarily connected with the photodynamic activity. The addition of 1 M NaCl to the mixture of 4-nitroquinoline I-oxide and DNA, completely abolished the effect of photoirradiation, and no breakdown of guanine in either double-helix or single-stranded DNA was observed. By degassing the mixture of DNA and 4-nitroquinoline I-oxide before photoirradiation, the photodynamic action of 4-nitroquinoline I-oxide was completely inhibited.
Of special interest in this work is that 4-hydroxyaminoquinoline 1-oxide acts chiefly on the glandular stomach, especially on the pylorus mucosa, whereas 4-nitroquinoline 1-oxide acts mainly on the forestomach. Regarding the carcinogenic potencies of the other derivatives of 4-nitroquinoline 1-oxide, several papers have been presented. LACASSAGNE, Buu-HoI and ZAJDELA (1960) showed that subcutaneous injection of 4-nitroquinaldine 1-oxide produced tumor while skin painting failed to develop any tumor neither on C57b1 strain nor on XVIInc strain, yet painting of 4-nitroquinoline 1-oxide, as already mentioned, can develop epithelioma in the same experimental conditions on the skin of the former strain.
This yield did not change when the order of application of the two carcinogens was reversed. In another series of experiments, mice, after being given 10 or 20 applications of 4-nitroquino1ine l-oxide, were allowed 200 days rest before they were given 10 applications of 20-methy1cho1anthrene, or mice were given applications of the two drugs in reverse order with 200 days rest during each application. In all the groups alike, tumors were produced at the rate of 40 to 500/0, and the latent time of tumor induction after the second treatment was also about the same.