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By Edwin H. Flynn

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Example text

In contrast to the foregoing, Demain et al. (1963) examined approximately 200 marine microorganisms, 273 known bacterial species, and 99 actinomycete cultures and found none to cleave cephalosporin C to 7-ACA. In a similar study Nuesch et al. (1967) tested many actinomycetes, bacteria, and fungi but could not demonstrate the ability of any culture to hydrolyze cephalosporin C. Other investigators such as Huang et al. (1963), Claridge et al. (1963), Erickson and Bennett (1965), and Sjöberg et al.

781, 803 Pénicillium chrysogenum Wis. 49-408 Pénicillium sp. L. S. Pat. 3,150,059 Cole (1966) Cole (1966) Cole and Rolinson (1961) Cole (1966) Uri et al (1963) Vanderhaeghe et al. (1968) Singh et al. (1969) Brandi (1965) Waldschmidt-Leitz and Bretzel (1964) Huang et al. (1960) Cole (1966) Erickson and Bennett (1965) Cole (1966) Cole (1964) Batchelor et al. (1961); Rolinson et al. (1960b) Uri et al. (1963) Uri et al. (1963) Uri et al. (1963) 2. 7-AMINOCEPHALOSPORANIC AND 6-AMINOPENICILLANIC ACIDS Table II ENZYMATIC HYDROLYSIS OF PHENOXYMETHYLPENICILUN 33 36 F.

69015 Escherichia coli Escherichia coli Escherichia coli Escherichia coli Escherichia coli Escherichia coli (enzyme bound to celllulose) Micrococcus lysodeikticus Micrococcus roseul· Mycobacterium phlei Nocardia FD4697 Pénicillium chrysogenum Proteus rettgeri Streptomyces lavendulae Conditions and comments Enzyme source Achromobacter sp. L. L. 731 Cephalosporium sp. L. L. 781, 803 Pénicillium chrysogenum Wis. 49-408 Pénicillium sp. L. S. Pat. 3,150,059 Cole (1966) Cole (1966) Cole and Rolinson (1961) Cole (1966) Uri et al (1963) Vanderhaeghe et al.

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