By Robert D. Goldman, Robert V. Zackroff, Peter M. Steinert (auth.), Robert D. Goldman, Peter M. Steinert (eds.)
Research job on intermediate filaments (IF) has elevated dramatically during the last decade. For the main half, this surge of curiosity is because of their identity as ubiquitous components of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the truth that we all know little or no concerning their features. In sharp distinction to the opposite significant cytoskeletal platforms, microfilaments and microtubules, IF express a excessive measure of heterogeneity in regards to their protein subunit composition. certainly, you can still in basic terms wonder on the variety of assorted IF polypeptides, their linked proteins (IFAP) and, for that reason, the variety of genes excited about encoding the a number of ingredients of many of the IF networks present in diversified cellphone forms. The chapters during this e-book exhibit how a number of experimental ways involv ing mobile, molecular, biochemical, and immunological equipment were applied to generate information about the constitution and serve as of IF. To this finish, we've got accumulated jointly chapters from specialists within the significant fields of IF study. In every one bankruptcy, the authors have mixed studies of the on hand clinical literature with their very own rules on present and destiny instructions for IF examine. The chapters were divided into 5 significant sections that are curious about the subcellular association of IF, the molecular constitution of IF, the differential expression of IF genes, descriptions of associ ated proteins desirous about the intracellular association of IF, and at last an research of the adjustments noticeable in IF in pathological conditions.
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Extra info for Cellular and Molecular Biology of Intermediate Filaments
Panel a shows accumulation of vimentin-enriched "spots" near the nucleus (N) at 30 min postinjection. Panel b shows the location of biotinylated vimentin at 1 hr postinjection; and panel c shows complete IF-like network of biotinylated vimentin at 2 hr postinjection. Double-label fluorescence observations with vimentin antibody have demonstrated that the biotinylated "network" and the endogenous "network" are superimposed. See Vikstrom et al. (1989) for details. (al x 1042; (bl x 1350; (cl x 1065.
Natl. Acad. Sci. USA 78: 298-302. , 1980, The synthesis and distribution of desmin and vimentin during myogenesis in vitro, Cell 19:263-275. , and Somlyo, A. , 1985, Structure of smooth muscle, in Calcium and Contractility: Smooth Muscle (A. K. Grover and E. E. , pp. 1-36. , 1981, Comparison of the proteins of two immunologically distinct intermediatesized filaments by amino acid sequence analysis: Desmin and vimentin, Proc. Natl. Acad. Sci. USA 78: 4120-4123. , 1982, The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins, EMBO J.
Cell Bioi. 38:224-229. Zackroff, R. , and Goldman, R. , 1979. In vitro assembly of intermediate filaments from baby hamster kidney (BHK-21) cells, Proc. Natl. Acad. Sci. USA 76:6226-6230. 2 Intermediate (IO-nm) Filaments in Muscle Marvin H. Stromer 1. Introduction The purpose of this chapter is to provide an overview of 1O-nm filaments in smooth, skeletal, and cardiac muscle with an emphasis on newer developments. The intent was not to provide an exhaustive literature review but, instead, to include a sampling of research from different laboratories.