By Ren-Ke Li, Richard D. Weisel
Cardiac Regeneration and service, quantity reviews using biomaterials, on my own or mixed with mobile remedy, in supplying tissue-engineered constructs to fix the injured middle and stop or opposite center failure.
Part one explores the range of biomaterials to be had for cardiac fix, together with nanomaterials and hydrogels. additional chapters discover using biomaterials to augment stem mobilephone treatment for restoring ventricular functionality and producing stem cell-modified intravascular stents. half specializes in tissue engineering for cardiac fix, together with chapters on decellularized biologic scaffolds, artificial scaffolds, cellphone sheet engineering, maturation of sensible cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro purposes, and scientific concerns for cardiac tissue engineering. eventually, half 3 explores vascular home improvement, together with chapters highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.
Cardiac Regeneration and service, quantity Two is complemented by way of an preliminary quantity masking pathology and treatments. jointly, the 2 volumes of Cardiac Regeneration and service provide a accomplished source for clinicians, scientists, or academicians fascinated by cardiac regeneration, together with these drawn to cellphone treatment, tissue engineering, or biomaterials.
- Surveys the range of biomaterials to be had for cardiac fix, together with nanomaterials and hydrogels.
- Focuses on tissue engineering for cardiac fix together with medical issues for cardiac tissue engineering
- Explores vascular home improvement, highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels
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Additional info for Cardiac regeneration and repair: Biomaterials and tissue engineering
Unfortunately, beneficial effects in cardiac function and LV dimensions were not seen, potentially because the end point of the study was too early to detect differences. Of the many studies investigating injectable hydrogels for cardiac repair, relatively few have examined how material properties affect the outcomes on post-MI repair and/or regeneration. Ifkovits et al. (2010) attempted to study one aspect of injected hydrogels – material stiffness – through an ovine MI model. g. time of gelation, tissue distribution after injection, degradation rate).
Sens Actuator B-Chem. 78:279–84. 42. Cui Y, Wei QQ, Park HK, and Lieber CM (2001). Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. Science. 293:1289–92. 43. Sato M, Nakajima T, Goto M, and Umezawa Y (2006). Cell-based indicator to visualize picomolar dynamics of nitric oxide release from living cells. Anal Chem. 78:8175–82. 2 Hydrogels for cardiac repair J. J. WANG and K. L. 17 Abstract: In the last decade, advancements have been made towards developing injectable hydrogels for the purpose of cardiac repair.
Compared with synthetic polymers, naturally derived materials have the advantage of greater biocompatibility, being biodegradable with non-toxic degradation products, and most possess inherent motifs for cellular interactions. Using a naturally derived hydrogel, Christman et al. (2004a) were the first to demonstrate that injection of a biomaterial alone is sufficient to attenuate the decline of cardiac function in a rat MI model. , 2004a). , 2004b). Fibrin glue is formed by enzymatic polymerization of fibrinogen, a plasma glycoprotein involved in the clotting cascade.