By K.G. Clarke (Auth.)
Biotechnology is an expansive box incorporating services in either the existence technological know-how and engineering disciplines. In biotechnology, the scientist is worried with constructing the main beneficial biocatalysts, whereas the engineer is directed in the direction of strategy functionality, defining stipulations and methods that may maximize the creation strength of the biocatalyst. more and more, the synergistic influence of the contributions of engineering and existence sciences is known as key to the interpretation of recent bioproducts from the laboratory bench to advertisement bioprocess. primary to the winning recognition of the bioprocess is a necessity for strategy engineers and existence scientists useful in comparing organic structures from a cross-disciplinary perspective. Bioprocess engineering goals to generate center potential via an realizing of the complementary biotechnology disciplines and their interdependence, and an appreciation of the demanding situations linked to the applying of engineering rules in a existence technology context. preliminary chapters specialise in the microbiology, biochemistry and molecular biology that underpin biocatalyst strength for product accumulation. the next chapters strengthen kinetic and mass move ideas that quantify optimal approach functionality and scale up. The textual content is large in scope, when it comes to bioprocesses utilizing bacterial, fungal and enzymic biocatalysts, batch, fed-batch and non-stop innovations and loose and immobilised configurations.
- Details the applying of chemical engineering rules for the advance, layout, operation and scale up of bioprocesses
- Details the data in microbiology, biochemistry and molecular biology appropriate to bioprocess layout, operation and scale up
- Discusses the importance of those lifestyles sciences in defining optimal bioprocess performance
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Additional info for Bioprocess Engineering. An Introductory Engineering and Life Science Approach
There are two types of nucleic acids: ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). RNA is formed from nucleotides containing ribose with adenine, guanine cytosine or uracil as a base. DNA is formed from nucleotides containing deoxyribose with likewise adenine, guanine and cytosine as bases but which have thiamine in place of uracil. Nucleic acids are formed by the polymerisation of the nucleotides, catalysed by DNA polymerase or RNA 36 Published by Woodhead Publishing Limited, 2013 Metabolic macromolecules polymerase.
In the DNA molecule adenine and thiamine are known as complementary base pairs as are cytosine and guanine. 9 The nucleotides RNA (a) and DNA (b) 37 Published by Woodhead Publishing Limited, 2013 Bioprocess engineering The sequence of nucleotides in the DNA is what ultimately determines the sequence of amino acids in the proteins. As all enzymes are proteins, it is the DNA in the first instance that dictates which enzymes are produced and consequently, the biochemical reactions which they catalyse.
A high molecular mass heterogeneous organic polymer. Only the L-stereoisomers are found in living organisms. The convolution of the helices and their grouping gives rise to a spherical or ellipsoidal protein configuration coining their naming as globular proteins. Naturally most stable configuration. A nucleotide analogous to NAD+, nicotinamide dinucleotide phosphate (NADP+), occurs in specific reactions. In this molecule, the ribose attached to the adenine is phosphorylated. NAD+ and NADP+ are sufficiently different as to not be interchangeable.