By K. K. Conzelmann (auth.), Professor Yoshihiro Kawaoka DVM, PhD (eds.)
Negative-strand RNA viruses, so named end result of the polarity in their genomic RNA to mRNA, comprise very important human and non-human pathogens. opposite genetics, a method that enables new release of recombinant viruses, used to be first constructed for negative-strand RNA viruses in 1989. for the reason that then, it has sped up the speed of study on those viruses, resulting in a wealth of latest wisdom that differently could were tough to procure. outstanding achievements that may be attributed to opposite genetics contain the creation of inactivated and dwell vaccine applicants and of vaccine and gene move vectors.
This quantity covers significant advances in opposite genetics concepts during the last decade, cutting-edge simple technological know-how and the medical implications of experimental findings. this could re-light curiosity in negative-strand RNA viruses between readers, together with these in different disciplines, resulting in additional growth in knowing those very important viruses and in constructing potent measures of regulate.
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Extra info for Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics
44 In Vitro Reconstitution of Influenza Virus Ribonucleoprotein Complexes. . . . 45 3 Cell Culture Systems to Study Influenza Virus Replication . 46 4 Ribonucleoprotein Transfection Method . . . . . . 47 5 A System for the Mutagenesis of Any Influenza Virus Gene Segment . 49 6 RNA Polymerase I System . . . . . 50 7 Generation of Influenza A Virus Entirely from Plasmids-RNA Polymerase I System 51 8 The RNA Polymerase 1/11 System for the Generation of Influenza A Virus 52 9 Robustness of the RNA Polymerase I System 52 10 Generation of Virus-like Particles.
J Gen Virol82:2895-2903 Haller AA, Miller T, Mitiku M, Coelingh K (2000) Expression of the surface glycoproteins of human parainfluenza virus type 3 by bovine parainfluenza virus type 3, a novel attenuated virus vaccine vector. J Virol 74:11626-11635 Hammond AL, Plemper RK, Zhang J, Schneider U, Russell SJ, Cattaneo R (2001) Single-chain antibody displayed on a recombinant measles virus confers entry through the tumor-associated carcinoembryonic antigen. J Virol 75:2087-2096 Hardy RW, Harmon SB, Wertz GW (1999) Diverse gene junctions of respiratory syncytial virus modulate the efficiency of transcription termination and respond differently to M2- mediated antitermination 12.
Annu Rev Biochem 71:887-917 Sidhu MS, Chan J, Kaelin K, Spielhofer P, Radecke F, Schneider H, Masurekar M, Dowling PC, Billeter MA, Udem SA (1995) Rescue of synthetic measles virus minireplicons: measles genomic termini direct efficient expression and propagation of a reporter gene. Virology 208:800-807 Smallwood S, Moyer SA ( 1993) Promoter analysis of the vesicular stomatitis virus RNA polymerase. Virology 192:254-263 Spielhofer P, Bachi T, Fehr T, Christiansen G, Cattaneo R, Kaelin K, Billeter MA, Nairn HY (1998) Chimeric measles viruses with a foreign envelope.