By L. A. Sklar, W. N. Swann, S. P. Fay, Z. G. Oades (auth.), Jack Y. Vanderhoek (eds.)
Intercellular verbal exchange in multicellular organisms allows cells to reply to environmental alterations. Intercellular sign transduction transmitters comprise hormones, peptide development components, neurotransmitters in addition to a few lipid-soluble mediators. as soon as signalling molecules are certain to their mobilephone floor receptors, a number of intracellular signs are generated which adjust the Qehavior of the objective phone. The IXth foreign Washington Spring Symposium on the George Washington college in Washington, D.C. was once equipped to evaluate the present prestige of the sphere of sign transduction approaches and regulatory mechanisms. The symposium was once hung on could 8-'.2, 1989 and was once attended by way of greater than one thousand scientists from 30 nations. many of the papers provided on the plenary classes were gathered during this quantity. the 1st component of this e-book information the motion and rules of receptors akin to ,B-pdr.'nergic receptors and receptors for EGF, insulin, leukotrienes, phosphoinositides and prostaglandins. part makes a speciality of the kinfolk of guanine nucleotide regulatory proteins (G proteins). those G proteins are recognized to mediate the coupling of receptor-mediated indications to numerous intracellular effector structures. Papers are awarded describing the intracellular localization of G proteins, the usage of G protein antibodies, the interplay of G proteins with tubulin and the involvement of G proteins within the legislation of ion channels, adenylate cy~lase and within the activation of neutrophils and T cells. within the 3rd part, a number of papers describe the second one messenger position of phosphoinositides in addition to the legislation of phosphoinositide production.
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Extra resources for Biology of Cellular Transducing Signals
1989, The action of isle 1 activating protein on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes. Biochem J, 235:145. , 1987, Tyrosine phosphorylation of common and specific sets of cellular proteins induced by insulin, IGF-I and EGF in the intact cell, J BioI Chern, 262:7342. D. , Plenum Press, New York. , 1985, The molecular mechanism of insulin action, Annual Rev Med, 36:429. , 1982, Structure of the insulin receptors and its subunits, J BioI Chern 257:10392.
HL-60 cells that were induced to differentiate into PMN 3 leukocytic lineage by incubation with DMSO, displayed approximately 14,400 [ H]LTD4 binding sites/cell with a mean Kd of 33 nM, which was similar to that of kD human PMN leukocytes, with identical stereoselectivity (Fig. 1). Recent studies by Sarau et al. (1989) d~monstrated that preparations of membranes from U937 cells exhibit [ H]LTD4 receptors, which increased in association with the induction of differentiation (Table I). 22 Structural Properties of Leukotriene Receptors Human PMN leukocyte receptors have been solubilized by the zwitterionic detergent CHAPS (Koo, Healy & Goetzl, 1988).
Rev. , 56:881. Casey, M. , and Mitchell, M. D. (1987) Epidermal growth factor-stimulated prostaglandin E2 production in human amnionic cells:specificity and nonesterified arachidonic acid dependency. Mol. , 53:169. , and Ruggiero, M. (1987) Polyphosphoinositide metabolism is rapidly stimulated by activation of a temperature-sensitive mutant of Rous sarcoma virus in rat fibroblasts. Oncogene, 2:37. Di Fiore, P. , Pierce, J. , Fleming, T. , King, C. , and Aaronson, S. A. (1987) Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH/3T3 cells.