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Download Biochemical Targets of Plant Bioactive Compounds: A by Gideon Polya PDF

By Gideon Polya

This completely listed ebook summarizes a wealth of knowledge at the biochemical pursuits of plant shielding compounds, and is an a useful reference for all biomedical execs.

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Additional resources for Biochemical Targets of Plant Bioactive Compounds: A Pharmacological Reference Guide to Sites of Action and Biological Effects

Example text

A variety of angular and linear furanocoumarins inhibit inducible N O synthase expression, including isopsoralen, pimpinellin, sphondin, byakangelicol, oxypeucedanin, cnidilin and xanthotoxin. Isopsoralen and psoralen inhibit both monoamine oxidases A and B. Pyranocoumarins ( C 5 0 I Phe I pyran-2-one) include a variety of angular and linear compounds. A number of angular pyranocoumarins are spasmolytic and vasodilatory, notably the Ca'+ channel blocker visnadin. The inophyllums B and P from Calophyllu~nionophyllum (Guttiferae) are inhibitors of HIV-1 reverse transcriptase.

The parent compound is chalcone (1,3-diphenyl-2-propen-l-one or benzylideneacetophenone; Phe-CH=CH-CO-Phe), the ring numbering being 1-6 (benzylidene phenyl) and 1'-6' (acetophenone phenyl). Chalcone variants derive from hydroxy, prenyl (isopentenyl) and glycosyl substituents. Phenols are weak acids and as such can act as "protonophores" to increase the proton (H+)permeability of the mitochondria1 inner membrane and hence act as "uncoupling" inhibitors of the key ATP-providing process of oxidative phosphorylation.

Unsaturated pyrimidine (mC4N2) and purine (mC4N2 I C3N2; pyrimidine 1 imidazole) derivatives are involved in RNA and DNA structure and biosynthesis as well as related compounds used in signalling and for "defensive" purposes. The bases found in RNA (ribonucleic acid) are the purine heterocyclics adenine (6-aminopurine) and guanine (2-amino-6-oxypurine) and their "complementary" pyrimidine bases uracil (2,4-dioxypyrimidine) and cytosine (2-oxy-4-aminopyrimidine), respectively (Section 1, Appendix).

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