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Download Best Practice & Research Clinical Haematology Volume 24, by W. Fibbe PDF

By W. Fibbe

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Extra info for Best Practice & Research Clinical Haematology Volume 24, Issue 1 March 2011

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The morphology of CD271dim and CD271bright cells was evaluated by staining of sorted cells with Giemsa. 29 30 A. -J. Bühring / Best Practice & Research Clinical Haematology 24 (2011) 25–36 Fig. 2. CD56 defines a subset of MSC. 2 but not 39D5 is expressed on natural killer cells from peripheral blood. B) CD56 is expressed on cells of a CD271bright MSC subset. C) CD271brightCD56þ and CD271brightCD56À BM cells are clonogenic. CFU-F derived from 500 FACS-sorted cells were stained and scored as described.

Heterogeneity of individual MSC clones has been reported by several groups, who demonstrated that the developmental and proliferative potential was highest in cells giving rise to large colonies, whereas small-sized colonies were derived from cells with limited differentiation and proliferation capacity [6]. Sorting of single cells into culture plates does not only provide information about the growth characteristics of individual MSC clones but also about the frequency of MSC clones with defined differentiation potential.

Whereas the lineage, nature, and potential diversity of pericytes across tissues remains to be defined (any reference to “pericytes” as a uniform category, or even a uniform cell type [52,53] is simply unwarranted), each and every feature so far indicated as characteristic of a “pericyte” is indeed found in bone marrow osteoprogenitors. Expression of a host of smooth muscle gene products, of extracellular matrix proteins characteristic of basement membrane, and of growth factor receptors characteristic of mural cells is uniquely blended, in the transcriptome of bone marrow osteoprogenitors, with the expression of markers signifying a commitment to the osteogenic lineage, but not a mature osteoblastic phenotype [23].

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