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Download Advances in Research on Neurodegeneration: Volume 6 by Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. PDF

By Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. Ransmayr (eds.)

The publication comprises unique articles and stories awarded on the sixth overseas wintry weather convention on Neurodegeneration, held from November 20–23, 1997 in Kitzbuhel/Austria. the purpose of this convention was once to give and speak about contemporary information at the interface among neuroimmunology and neurodegeneration, specifically susceptibility to autoimmune and neurodegenerative procedures, neuroprotection and restorative therapy recommendations. those matters have been mentioned within the gentle of contemporary advancements in a number of sclerosis, Parkinson’s ailment, amyotrophic lateral sclerosis, Huntington’s ailment and multisystem atrophy. The articles spotlight subject matters, that are relatively attention-grabbing for the clinician and the neuroscientist. the various neuroprotective techniques have already been constructed or are at the moment clinically investigated. The neuroprotective position of deep mind stimulation, antiglutamatergic treatment and apomorphine can be proven in scientific reviews within the close to destiny. this is often additionally the case for destiny healing ways to recovery of the broken worried method, reminiscent of somatic gene treatment, implantation of genetically converted cell-lines and medically managed and directed improvement of embryonic cells. The convention highlighted the position of the glia, which turns out to play a key function, either in characteristically as neuroimmunological and neurodegenerative problems labeled ailments, as indicated above. the themes mentioned within the publication are major for contemporary advancements in medical neurology and neuroscience, as proven within the present literature and at overseas congresses.

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To our best knowledge, there are no such long-term (5 year) study comparing the outcome of patients treated from the early stages with pramipexole versus levodopa. However, a prospective two-year study is now on-going with this compound, but might be too short to detect truely clinically relevant differences. Ropinirole has also been compared to bromocriptine in a double-blind parallel-group study conducted in 335 patients with early idiopathic Parkinson's disease. , 1998). After 3 years of treatment, and despite the fact that ropinirole is a selective agonist at the D2 (D3) receptors, while bromocriptine also binds to other receptors like the serotonergic ones - which have been claimed to participate in the pathophysiology of various psychiatric syndromes - both drugs induced the same amount of psychiatric adverse events (9% of each group experienced hallucinations).

Ann Inst Pasteur 19: 625-646 Rivers TM, Sprunt DH, Berry GP (1993) Observations on attempts to produce acute disseminated encephalomyelitis in monkeys. J Exp Med 58: 39-53 Sawcer S, Jones HB, Feakes R, Gray J, Smaldon N, Chat away J, Robertson N, Clayton D, Goodfellow PN, Compston A (1996) A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 13: 464-468 SchlUsener H, Wekerle H (1985) Autoaggressive T lymphocyte lines recognize the encephalitogenic region of myelin basic protein; in vitro selection from unprimed rat T lymphocyte populations.

27 Molecular mimicry and multiple sclerosis Table 1. Evolution of the concept of molecular mimicry. KKHYHES Wucherpfennig and Strominger (1995) MBP(83-97) HSV-T (153-167) ENPVVHFFKNIVTPR FRQLVHFVRDFAQLL Wucherpfennig and Strominger (1995) MBP(87-99) Predicted peptide VHFFKNIVTPRTP GGLLAHVISAKKA Hemmer et al. (1998a) MBP(89-98) Predicted peptide FFKNIVTPRT WYALLPSCKG Hemmer et al. (1998a) Amino acid sequences of cross-reacting peptides are reported using the one letter code. e. identical amino acids in corresponding positions of crossreacting peptides, are shown in bold underlined characters.

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