By Ahmed Ammar MD., Ph.D. (auth.), Assoc. Prof. Dr. Christer Lindquist, Assoc. Prof. Dr. Douglas Kondziolka, Assoc. Prof. Dr. Jay S. Loeffler (eds.)
Radiosurgery is a speedily constructing kind of minimally invasive neurosurgery. chosen papers from the 1st assembly of the foreign Stereotactic Radiosurgery Society in Stockholm, June 1993, mirror present multidisciplinary methods to tricky intracranial neurosurgical difficulties. Neurosurgeons, radiotherapists, oncologists, radiobiologists, physicists and representatives of numerous different medical disciplines tell concerning the cutting-edge of radiosurgical therapy of a mess of intracranial difficulties reminiscent of arteriovenous malformations, pituitary and pineal tumors, vestibular schwannomas in addition to metastatic mind tumors and gliomas.
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Extra resources for Advances in Radiosurgery: Proceedings of the 1st Congress of the International Stereotactic Radiosurgery Society, Stockholm 1993
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More baseline information is needed in this regard. Second, clinical responses after single high dose radioneurosurgery appear to be more positive than results that would be predicted from an assumption of 20% tumor hypoxia (Wahlberg, unpublished data, 1993) which suggests that intratumor hypoxia may not be as bad a problem as postulated. Clinical information indicates for example, that intracerebral melanoma appears to be responding well to doses used in radiosurgery (Kihlstrom, unpublished data presented at the 1st International Conference on Stereotactic Neurosurgery, Stockholm, Sweden, June, 1993).
Weichselbaum RR, Nove J, Little JB (1980) X-ray sensitivity of human tumor cells in vitro. Int J Radiat Oncol BioI Phys 6: 437-440 48. Weichselbaum RR, Schmit A, Little JB (1982a) Cellular repair factors influencing radiocurability of human malignant tumours. Br J Cancer 45: 10-15 49. Weichselbaum RR, Malcom AW, Little JB (I 982b) Fraction size and the repair of potentially lethal radiation damage in a human melanoma cell line. Radiol 142: 225-229 50. Weichselbaum RR, Little JB (1983) The heterogeneity in response of human tumor cells to x irradiation in vitro.
M. was 484 nmol/1. After the Gamma Knife treatment she had a total clinical improvement while on metapyrone and there was an obvious, radiologically demonstrated reduction in tumour volume (Fig. 3b). m. serum cortisol rose to 450 nmol/l. 92. There was no particular special change at operation that could definitely have been related to the previous radiosurgery. The histological examination again showed no sign of clear cut necrosis (Fig. 2a and b). There may have been some more diffuse fibrosis than usual, but it was not marked.