By Frank J. Dixon (Ed.)
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Extra resources for Advances in Immunology, Vol. 42
Thus, the capacity to tolerize B cells is comparable to the capacity to stimulate those cells and is equally affinity dependent. These findings constitute evidence that the affinity required to tolerize B cells as they mature through the tolerance gauntlet of self-antigen is a higher affinity than that ultimately required to trigger these cells once they mature. This extrapolates to the conclusion that the mature splenic B cell population could include a substantial number of cells that recognize self-antigenic determinants but have too low an affinity for these antigens to have been tolerized as immature B cells.
However, in young mice of all tested strains, these V region combinations are not expressed within the normal B cell repertoire. The reasons for the late expression of anti-PC antibodies utilizing non-S107 V, gene segments is currently the subject of intensive investigation. Nonetheless, these findings serve as strong 32 NORMAN R. KLINMAN AND PHYLLIS-JEAN LINTON evidence for the nonrandom utilization of V, genes in certain combinations within the normal B cell repertoire of young mice. D. THEINTERRELATIONSHIP OF CLONAL EXPANSION AND V GENE EXPRESSION Although we have gained a considerable amount of new information concerning the cellular and molecular aspects of B cell repertoire expression, two very important aspects of this process remain relatively unexplored.
1987). B cells responsive to most antigenic determinants is determined by the frequency with which B cells of these specificities have emerged from the developing bone marrow progenitor pool and appears to be influenced little, if at all, by the environmental milieu of the developing B cells. This conclusion is convincingly reinforced by a more detailed 38 NORMAN R. KLINMAN AND PHYLLIS-JEAN LINTON analysis of the clonotypic composition of the responding precursor cell populations. , 1976). Table I11 displays the reactivity patterns available among a surveyed population of sIgbone marrow B cells obtained from BALB/c mice in comparison with a similar survey carried out using mature splenic B cells of BALB/c mice.