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Download Advances in Immunology, Vol. 16 by F.J. Dixon, Henry G. Kunkel (Eds.) PDF

By F.J. Dixon, Henry G. Kunkel (Eds.)

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1973) Litwin el al. (1973) Litwin et al. (1973) van Loghem and Natvig (1970) van Loghem and Natvig (1970) Natvig and Kunkel (1969); Natvig et al. (1971) van Loghem and Natvig (1970) Natvig and Kunkel (1969); Natvig et al. (1971) Kunkel et al. , 1973). The homozygous state has as yet not been encountered. However, this gene is implicated in some cases of immune deficiencies, where it appears to interact with other abnormal genes to produce disease. , 1970). There are also a number of genes in the population where one genetic type of immunoglobulin is produced at a lower level.

With the exception of some rare G m ( b ) subtypc markers, Gm(c3) and (c'), all known genetic markers are distributed widely in differing populations. It would be much more difficult to conceive of these genetic markers developing independently in all these populations than to explain their different relationships by a single or a small series of reconibinational events. As previously shown there are some gene complexes that are more prevalent in certain populatioiis than others, for example: 24 J.

Anti-galactomannan 38 J. R . NATVIG AND H. G. KUNKEL from an accumulation of the iron. In a somewhat analogous fashion the anti-lipoproteins interfere with lipid transport and cause lipid accumulations in various organs resulting in malfunction. Several of these have been studied in the authors’ laboratories, and lipid deposits in the skin are a frequent finding. In one case the deposits were extremely widespread including organs such as thc liver and spleen. In this instance the deposits were surrounded by plasma cells.

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