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Download A Practical Approach to Toxicological Investigations by Alan Poole, George B. Leslie PDF

By Alan Poole, George B. Leslie

First released in 1989, this e-book recognizes that new medications, meals ingredients and different compounds have to be conscientiously screened for poisonous side-effects. the majority of this learn is dedicated to the sensible questions of 'what toxicological experiences should still we perform?' and 'how may still we practice them?' Compounds which suffer toxicity trying out could be comfortably classified as these that are meant for management to guy and people which aren't. the previous comprise prescription drugs for use medicinally or prophylactically and chemical compounds that are additional to our nutrients, beverages or medication to enhance their balance, visual appeal or palatability. because it is on prescription drugs that the main entire toxicological reviews are normally played, this ebook has been directed basically in the direction of to toxicological overview of capability new medicinal drugs. the foundations and method of toxicological review of alternative sorts of compounds are primarily related.

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Extra resources for A Practical Approach to Toxicological Investigations

Sample text

This latter point is most important to the toxicologist since chronic studies rely on Requirements for clinical trials and marketing giving dose levels which are multiples of the pharmacologically effective dose and proposed human dose. Clinical trials should provide: Pharmacology data: dose-response relationships, therapeutic index, optimum dose, etc. Pharmaco kinetic data: absorption, bioavailability, distribution, metabolism, protein binding, excretion, etc. Drug interactions: important for drugs with high protein binding, metabolised extensively in the liver (effect of metabolic inducers).

As a usual procedure all drinking water isfilter-sterilisedto ensure animals are not exposed to pathogenic agents which may confuse toxicological evaluation. 2 OTHER RODENTS Much of what has been said about rats and mice applies in principle to other rodents such as Syrian hamsters, gerbils and guinea pigs which are all readily available from commercial Other rodents 39 breeders. g. into skin, rectum, eye), these other rodents are seldom used in toxicity studies and are not available to the same standards as are rats and mice.

Length of studies and parameters to be measured: recommendations for duration of exposure are not well formulated and contain general statements such as 'duration and route of administration should be similar to man'. Naturally in any study the length of exposure in the experimental animal may very well depend upon the antigenicity of the compound. g. blood pressure, electrocardiography and/or other cardio-vascular measurements. Attention should also be paid to determination of immunotoxicity. In most cases emphasis is placed on safety pharmacology rather than toxicity.

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