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Download A Critical Review of the 2001 Literature Preceded by Two by Gordon W. Gribble and Thomas L. Gilchrist (Eds.) PDF

By Gordon W. Gribble and Thomas L. Gilchrist (Eds.)

This quantity of development in Heterocyclic Chemistry (PHC) is the fourteenth annual overview of the literature, protecting the paintings released on very important heterocyclic ring platforms in the course of 2001. during this quantity there are really expert stories. the 1st, by means of Jan Bergman and Tomasz Janosik, covers their paintings on sulfur-containing indoles. the second one, by way of David Knight, discusses five- endo -trig iodocyclisations. the following chapters, prepared via expanding heterocycle ring measurement, overview fresh advances within the box of heterocyclic chemistry with emphasis on synthesis and reactions.

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Extra resources for A Critical Review of the 2001 Literature Preceded by Two Chapter on Current Heterocyclic Topics

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Knight 34 ether effect. Displacement by azide usually was the most efficient. Thus, exposure of iodotetrahydrofuran 27 to sodium azide in DMF at 80~ for 2h gave the inverted azide 121 in 87% isolated yield <99JCS(P1)2143>. Subsequent hydrogenation in the presence of Boc anhydride <89TL837> then delivered a good yield of the protected amine 122. Stronger heating gave substantial amounts of the elimination product, the 2,5-dihydrofuran 123. Displacement by an oxygen nucleophile could be effected using caesium acetate in hot DMF <81JOC4321> to give acetate 124 in moderate yield; the use of potassium superoxide and 18-crown-6 also in DMF <75CC658> gave marginally better yields of the corresponding alcohol, typically 60-70% at most.

The relatively low levels of stereoselection in cyclizations of the foregoing examples of 'anti'-(E)-homoallylic alcohols can also be addressed by using the very bulky aryl selenide 145 <95JOC3572>; levels are increased to 49:1 using this novel reagent. SePh " = ,,E Z Z 'syn' 95 141 \ 142 Z ...... SePh ~E ...... 'anti' 98 -.. " OH Z 143 r 145 Z 144 A number of studies have also been carried out to assess the impact of potentially more interactive substituents on such selenocyclizations. Landais has suggested that steric effects are probably responsible for the predominant formation of diastereoisomers 147 from alkenols 146 <95TL2987; 95SLl191>.

Preliminary results also indicate that the corresponding N-Boc derivatives undergo similarly smooth iodocyclizations. This methodology should prove useful for the synthesis of annulated pyrroles, exemplified D. W. Knight 46 by a synthesis of the bicyclic core 246 of the antitumor antibiotic Roseophilin, by radicalmediated cyclization of the iodopyrrole 245 and oxidation <99TL6117>.

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